A legacy of innovative research

The Foundation for Embryonic Competence (FEC) is pleased to provide support to the following grant recipients:

2015

Erika Munch, MD

Fellow associate, Division of Reproductive Endocrinology and Infertility, University of Iowa Carver College of Medicine, Iowa City, Iowa

  • Title: Embryonic Gene Expression for Blastocyst Competence
  • Aim: To identify expression and location of differentially expressed gene products in good morphology blastocysts; to identify differentially expressed genes in good- and poor-morphology embryos and correlate these with ploidy status

Caroline Juneau, MD

Reproductive endocrinology and infertility fellow, Reproductive Medicine Associates of New Jersey, Department of Obstetrics and Gynecology, Rutgers, Robert Wood Johnson Medical School, New Brunswick, NJ

  • Title: En Motion, Embryo’s Natural Motion
  • Aim: To determine if dynamic embryo culture impacts embryo development and reproductive potential in comparison to static culture

Katherine (Kay) Green, MD

Reproductive endocrinology and infertility fellow, National Institutes of Health, Bethesda, MD

  • Title: Investigating the Embryonic Secretome in Relation to Aneuploidy and In Vitro Fertilization (IVF) Outcomes
  • Aim: To correlate embryonic secretome with embryologic and clinic outcomes

Manuel Doblado, MD

Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California, San Diego, CA

  • Title: Embryo Selection by Direct Assessment of the Gene Expression Profiles of Single Trophectoderm Cells
  • Aim 1: To delineate the technical and biological variable of RNAseq expression profiles in single TE cells
  • Aim 2: To test the ability of RNAesq expression profiles to distinguish between TEs from embryos of different pregnancy potential

2014

Linnea R. Goodman, MD

Reproductive endocrinology and infertility fellow, Department of Obstetrics and Gynecology, The Cleveland Clinic, Cleveland, OH

  • Title: Time-Lapse Imaging or Multinucleated Embryos and the Association With Aneuploidy Determined by Pre-implantation Genetic Screening
  • Aim: To examine the incidence and clinical implications of multinucleated embryos by using morphologic kinetics and the evaluation of chromosomal competence by blastocyst trophectoderm biopsy PGS

Daniel Kaser, MD

Clinical and research fellow, Center for Infertility and Reproductive Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

  • Title: Does Ultra-Low Oxygen Tension Enhance Development and Quality of Blastocysts in Clinical IVF
  • Aim: To determine whether reducing incubator oxygen tension from days 3 to 5 improves blastocyst formation or, from days 5 to 7, rescues more slowly developing blastocysts; to investigate whether use of sequential partial pressure of oxygen is superior to fixed partial pressure of oxygen for in vitro blastocyst development; to assess the amount of oxidative stress in spent media from embryos cultured under various oxygen atmospheres and measure the transcriptomic program and relative expression of key genes involved in the cellular response to oxidative stress

Meredith Provost, MD, PhD

Reproductive endocrinology and infertility fellow, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC

  • Title: The Effect of Progesterone on Early Embryo Metabolism and Development in the Rhesus Monkey (Macaca Mullata)
  • Aim: To investigate the role of progesterone (P4) in the control of metabolic activity in the developing embryo using the Rhesus monkey (Macaca mullata) as a model

Rachel Weinerman, MD

Reproductive endocrinology and infertility fellow, University of Pennsylvania, Philadelphia, PA

  • Title: The Effect of Blastocyst Vitrification in Super-Ovulated and Non-Superovulated Environments in the Mouse
  • Aim: To examine the effect of both the vitrification process and superovulated environment individually on embryo development and pregnancy outcome utilizing a mouse model

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